16/05/2022

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Moderna says booster dose of its Covid-19 vaccine appears protective against Omicron

NEW YORK (REUTERS) – Moderna said on Monday (Dec 20) that a booster dose of its Covid-19 vaccine appeared to be protective against the fast-spreading Omicron variant in laboratory testing and that the current version of the vaccine will continue to be Moderna’s “first line of defence against Omicron”.

The vaccine maker said the decision to focus on the current vaccine, mRNA-1273, was driven in part by how quickly the recently discovered variant is spreading.

The company still plans to develop a vaccine specifically to protect against Omicron, which it hopes to advance into clinical trials early next year.

“What we have available right now is 1273,” Dr Paul Burton, Moderna’s chief medical officer, said in an interview.

“It is highly effective, and it is extremely safe. I think it will protect people through the coming holiday period and through these winter months, when we’re going to see the most severe pressure of Omicron.”

The company said a two-dose course of its vaccine generated low neutralising antibodies against the Omicron variant, but a 50microgram booster dose increased neutralising antibodies against the variant 37-fold.

A higher, 100mcg booster dose of the same vaccine drove antibody levels even higher – more than 80 times pre-boost levels.

The data, which has not yet been peer reviewed, tested blood from people who had received the vaccine against a pseudovirus engineered to resemble the Omicron variant. It is similar to data recently discussed by top US infectious disease expert Anthony Fauci.

Dr Burton said it would be up to governments and regulators to gauge whether they want the enhanced level of protection that a 100mcg dose might confer.

The company said that the 100mcg dose was generally safe and well tolerated, although there was a trend toward slightly more frequent adverse reactions.

Moderna also tested the vaccine’s effectiveness compared to its prototype boosters that target multiple previous variants of concern, and said the results were similar.

US regulators authorised the 50mcg booster of Moderna’s vaccine in October. The first two shots of Moderna’s vaccine are both 100mcg.

Both the Moderna and the Pfizer-BioNTech vaccines have been linked to rare cases of heart inflammation, particularly in young men. Several studies have suggested that Moderna’s vaccine is likely to cause the heart inflammation at a higher rate.

Omicron, a highly contagious variant first identified last month in southern Africa, has raced around the globe and been reported in 89 countries, the World Health Organisation said on Saturday.

It said the number of Omicron cases is doubling in 1.5 to three days in areas with community transmission, but noted that much remains unknown about the variant, including the severity of the illness it causes.

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